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Heat-stable enterotoxin
Heat-stable enterotoxins (STs) are secretory peptides produced by some bacterial strains, such as enterotoxigenic Escherichia coli which are in general toxic to animals.
These peptides keep their 3D structure and remain active at temperatures as high as 100 °C.
==Function==
Different STs recognize distinct receptors on the surface of animal cells and thereby affect different intracellular signaling pathways. For example, STa enterotoxins bind and activate membrane-bound guanylate cyclase, which leads to the intracellular accumulation of cyclic GMP and downstream effects on several signaling pathways. These events lead to the loss of electrolytes and water from intestinal cells.
Heat-stable toxin 1 of entero-aggregative ''Escherichia coli'' (EAST1) is a small toxin. It is not, however, solely associated with entero-aggregative ''E. coli'' but also with many other diarrhoeic'' E. coli'' families. Some studies have established the role of EAST1 in some human outbreaks of diarrhoea. Isolates from farm animals have been shown to carry the astA gene coding for EAST1. However, the relation between the presence of EAST1 and disease is not conclusive.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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